A-094

Ascomycin solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₄₃H₆₉NO₁₂
• Numéro CAS: 104987-12-4
• Poids moléculaire : 792.01
• Numéro CE : 200-835-2
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1.0 mg/mL in acetonitrile
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −70°C
• Chaîne SMILES: CCC1\C=C(C)\CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)\C(C)=C\C4CCC(O)C(C4)OC
• InChI: 1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+
• Clé InChI: ZDQSOHOQTUFQEM-AMASXYNMSA-N

Description

Description générale

An internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution^® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants. The Snap-N-Spike^® format provides laboratories the ability to spike into their matrix of choice just before use and allows them to eliminate weighing operations of hazardous substances which significantly reduces occupational exposure hazards related to handling acutely toxic powders such as immunosuppressants.

Application

• Ascomycin macrolide for signal transduction studies: Investigation into the bioanalytical methods for ascomycin quantification in biological samples showcases its utility in pharmacokinetic studies, relevant for understanding its role in signal transduction pathways (Nguyen et al., 2021).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302 + H312 + H332,H319
• Conseils de prudence: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 35.6 °F - closed cup
• Point d'éclair (°C): 2 °C - closed cup