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850395C

Avanti

18:3 (Cis) PC

Avanti Research™ - A Croda Brand 850395C

Synonyme(s) :

1,2-dilinolenoyl-sn-glycero-3-phosphocholine

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About This Item

Formule empirique (notation de Hill):
C44H76NO8P
Numéro CAS:
2701-19-1
Poids moléculaire :
778.05
Code UNSPSC :
51191904
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

liquid

Conditionnement

pkg of 1 × 2.5 mL (850395C-25mg)
pkg of 2 × 4 mL (850395C-200mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 850395C

Concentration

10 mg/mL (850395C-25mg)
25 mg/mL (850395C-200mg)

Type de lipide

cardiolipins
phospholipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine is an unsaturated glycerophospholipid, with substitution of two chains of linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, along with choline as a headgroup.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine:
  • might be used in aqueous lipid-trehalose formulations to assess the long-term storage stability of lyophilized liposomes
  • might be used in phospholipid monolayer to study the instability of unsaturated phospholipids at specified conditions
  • has been used in aqueous sugar formulations or liposome formulations to characterize its degradation during lyophilization

Conditionnement

5 mL Clear Glass Sealed Ampule (850395C-200mg)
5 mL Clear Glass Sealed Ampule (850395C-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organes cibles

Central nervous system, Liver,Kidney

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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1,2-Dilinoleoyl-sn-glycero-3-phosphocholine ≥99% (TLC), lyophilized powder

Sigma-Aldrich

P0537

1,2-Dilinoleoyl-sn-glycero-3-phosphocholine

Jonathan F D Liljeblad et al.
Biophysical journal, 98(10), L50-L52 (2010-05-21)
The surface specific technique vibrational sum frequency spectroscopy has been applied to in situ studies of the degradation of Langmuir monolayers of 1,2-diacyl-phosphocholines with various degrees of unsaturation in the aliphatic chains. To monitor the degradation of the phospholipids, the
N M Payton et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 85(2), 306-313 (2013-04-10)
As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g., lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during lyophilization and/or during prolonged storage. The goal of the current
Nicole M Payton et al.
Journal of pharmaceutical sciences, 103(12), 3869-3878 (2014-10-14)
Because aqueous liposomal formulations containing multiply unsaturated lipids are susceptible to chemical degradation, these formulations are often lyophilized. Despite their limited chemical stability, interest in the use of multiply unsaturated lipids to promote intracellular delivery has increased considerably in recent

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