810604P
Avanti
16:0-16 Doxyl PC
Avanti Research™ - A Croda Brand 810604P, powder
Synonyme(s) :
1-palmitoyl-2-stearoyl-(16-doxyl)-sn-glycero-3-phosphocholine
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About This Item
Formule empirique (notation de Hill):
C46H90N2O10P
Numéro CAS:
Poids moléculaire :
862.19
Code UNSPSC :
51321705
Nomenclature NACRES :
NA.25
Produits recommandés
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 1 mg (810604P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 810604P
Type de lipide
ESR probes
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon.
Application
16:0-16 Doxyl PC has been used as a spin probe in electron spin resonance spectroscopy.
Actions biochimiques/physiologiques
Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.
Conditionnement
5 mL Clear Glass Sealed Ampule (810604P-1mg)
Notes préparatoires
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
The
Integrative Medicine - E-Book (2017)
The
The Membranes of Cells (2016)
Biopolymer nanovehicles for essential polyunsaturated fatty acids: Structure-functionality relationships
Semenova MG, et al.
Food Research International, 88, 70-78 (2016)
Anjali Gupta et al.
Journal of lipid research, 61(2), 252-266 (2019-12-21)
A fundamental feature of the eukaryotic cell membrane is the asymmetric arrangement of lipids in its two leaflets. A cell invests significant energy to maintain this asymmetry and uses it to regulate important biological processes, such as apoptosis and vesiculation.
An Ghysels et al.
Nature communications, 10(1), 5616-5616 (2019-12-11)
The functional significance of ordered nanodomains (or rafts) in cholesterol rich eukaryotic cell membranes has only begun to be explored. This study exploits the correspondence of cellular rafts and liquid ordered (Lo) phases of three-component lipid bilayers to examine permeability.
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