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700042P

Avanti

4β-hydroxycholesterol-d7

Avanti Research™ - A Croda Brand

Synonyme(s) :

cholest-5-ene-3b,4b-diol(d7)

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About This Item

Formule empirique (notation de Hill):
C27H39O2D7
Numéro CAS:
1246302-80-6
Poids moléculaire :
409.70
Code UNSPSC :
12352100
Nomenclature NACRES :
NA.25

Description

cholest-5-ene-3,4-diol-d7

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (700042P-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Conditions d'expédition

dry ice

Température de stockage

−20°C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D

Clé InChI

CZDKQKOAHAICSF-BZNWTYAPSA-N

Catégories apparentées

Description générale

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

Application

4β-hydroxycholesterol-d7 has been used:
  • as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
  • to spike serum samples for mass spectrometry measurements
  • as an internal standard for the quantification of human colon biopsies samples using HPLC-MS

Actions biochimiques/physiologiques

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Owein Guillemot-Legris et al.
Journal of Crohn's & colitis, 13(2), 218-229 (2018-10-09)
Inflammatory bowel diseases [IBD] represent a challenging health issue with a complex aetiology involving genetic and environmental parameters. Although our understanding of the pathophysiology of IBD has improved, much remains to be explored. In this context, bioactive lipids, more specifically
Mahmoud Hasan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1033-1034, 193-199 (2016-08-28)
Cytochrome P450 3A (CYP) enzymes are involved in the elimination of many drugs and are known to be regulated by several environmental factors. Thus, it was the aim of this study to develop and validate an analytical method allowing estimation
Sarah J Woolsey et al.
Basic & clinical pharmacology & toxicology, 118(4), 284-291 (2015-09-25)
Due to high basal interindividual variation in cytochrome P450 3A (CYP3A) activity and susceptibility to drug interactions, there has been interest in the application of efficient probe drug phenotyping strategies, as well as endogenous biomarkers for assessment of in vivo

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