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Merck
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933597

Sigma-Aldrich

Poly(Guluronate)

low endotoxin

Synonyme(s) :

Alginate, Bioink, Bioprinting, Guluronic Acid, Hydrogel, Ionic, Sodium Alginate

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About This Item

Formule linéaire :
(C6H8O6)n
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.21

Description

GPC 5-15 kDa

Niveau de qualité

100

Forme

(Solid chunks, fibres or powder)

Impuretés

<125 EU/g Endotoxin
<5 CFU/g Bioburden(Total aerobic)
<5 CFU/g Bioburden(fungal)

Couleur

white to off-white

Température de stockage

2-8°C

Catégories apparentées

Description générale

Sodium alginate is a natural linear polysaccharide derived from brown algae made up of blocks of B-D-mannuronate (M) and a-L-guluronate (G). Guluronate blocks that bind Ca2+ cations to form ionic bonds. Poly(guluronate) is isolated from alginate which can be used alone as a stabilizer or further modified to create additional functional groups.

Application

Sodium Alginate based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.

Caractéristiques et avantages

  • Sterile, low endotoxin
  • Batch control offers reproducible models for preclinical toxicology testing and drug screening
  • Extended shelf-life & stability

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Kuen Yong Lee et al.
Biomaterials, 25(13), 2461-2466 (2004-01-31)
Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have
K H Bouhadir et al.
Journal of pharmaceutical sciences, 89(7), 910-919 (2000-06-22)
We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly(aldehyde guluronate). Adipic dihydrazide was used
K Y Lee et al.
Journal of biomedical materials research, 56(2), 228-233 (2001-05-08)
Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range
David Leal et al.
Carbohydrate polymers, 92(1), 157-166 (2012-12-12)
Graft copolymers were prepared by formation of an amide bond between poly-α-L-guluronic acid (MW 24,000), isolated from sodium alginate and the free amino group of PNIPAAm-NH(2). SEM micrographs revealed the formation of a macroscopic network on the surface of the

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