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Merck
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Key Documents

921661

Sigma-Aldrich

Droplet generation and storage chip

Fluidic 488, COC

Synonyme(s) :

Microfluidics chip

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About This Item

Code UNSPSC :
42142600
Nomenclature NACRES :
NA.23

Description

Microfludic chip x1

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Application

Microfluidic generation of droplets can produce highly monodispersed droplets with high frequency (up to hundreds of kHz). Interest in droplet-based microfluidic systems has grown substantially, because microfluidics offers the ability to handle very small volumes (μl to fl) of fluids, provides better mixing, encapsulation, sorting, and sensing. Microfluidics can be used for high throughput experimentation. Microfluidic-based droplets have many diverse and varied applications such as particle synthesis and chemical analysis. Highly controlled droplet production also makes single cell analysis, or drug testing possible.

Droplet generation and storage chip, Fluidic 488, COC is made of COC (Cyclic olefin copolymer), and is designed to generate and capture droplets for on-chip optical analysis of single droplets. It features 24 rhombic storage units, each suitable to capture 108 individual droplets. With a combination of multiple T-junctions and a flow focusing nozzle, the channel design in the droplet generating area is a versatile tool for many different experimental settings.

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Microfluidic-assisted fabrication of carriers for controlled drug delivery.
Santos H A, et al.
Lab on a chip, 17, 1856-1883 (2017)
Dongfei Liu et al.
Lab on a chip, 17(11), 1856-1883 (2017-05-10)
The microfluidic technique has brought unique opportunities toward the full control over the production processes for drug delivery carriers, owing to the miniaturisation of the fluidic environment. In comparison to the conventional batch methods, the microfluidic setup provides a range
Recent advances of controlled drug delivery usingmicrofluidic platforms.
Li X, et al.
Advanced Drug Delivery Reviews, 128, 3-28 (2018)
Sharma T Sanjay et al.
Advanced drug delivery reviews, 128, 3-28 (2017-09-19)
Conventional systematically-administered drugs distribute evenly throughout the body, get degraded and excreted rapidly while crossing many biological barriers, leaving minimum amounts of the drugs at pathological sites. Controlled drug delivery aims to deliver drugs to the target sites at desired

Articles

Microfluidics for Nanoencapsulation of Nucleic Acids

Microfluidic assembly improves polyamine nanoencapsulation of nucleic acids, overcoming challenges like polydispersity and poor reproducibility.

Microfluidics for Nanoencapsulation of Nucleic Acids

Microfluidic assembly improves polyamine nanoencapsulation of nucleic acids, overcoming challenges like polydispersity and poor reproducibility.

Microfluidics for Nanoencapsulation of Nucleic Acids

Microfluidic assembly improves polyamine nanoencapsulation of nucleic acids, overcoming challenges like polydispersity and poor reproducibility.

Microfluidics for Nanoencapsulation of Nucleic Acids

Microfluidic assembly improves polyamine nanoencapsulation of nucleic acids, overcoming challenges like polydispersity and poor reproducibility.

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