900913

Tetrazine-PEG5-NHS ester

≥95%

• Synonyme(s) : Tz-PEG5-NHS
• Formule empirique (notation de Hill): C₂₇H₃₆N₆O₁₀
• Numéro CAS: 1682653-80-0
• Poids moléculaire : 604.61
• Numéro MDL: MFCD28505547
• Code UNSPSC : 12352108
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder or crystals
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: NHS ester
• Température de stockage: −20°C
• Chaîne SMILES: O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O

Description

Description générale

Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

Application

Tetrazine-PEG5-NHS ester (Tz-PEG₅-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable