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Key Documents

767654

Sigma-Aldrich

cis-Dichlorobis(dimethyl sulfoxide)platinum(II)

97%

Synonyme(s) :

cis-Dichlorobis(dimethylsulfoxido)platinum(II), Pt(DMSO)2Cl2

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About This Item

Formule empirique (notation de Hill):
C4H12Cl2O2PtS2
Numéro CAS:
Poids moléculaire :
422.25
Numéro MDL:
Code UNSPSC :
12161600
ID de substance PubChem :
Nomenclature NACRES :
NA.22

Niveau de qualité

Pureté

97%

Forme

solid

Pertinence de la réaction

core: platinum
reagent type: catalyst

Pf

218-224 °C

Chaîne SMILES 

Cl[Pt]Cl.CS(C)=O.CS(C)=O

InChI

1S/2C2H6OS.2ClH.Pt/c2*1-4(2)3;;;/h2*1-2H3;2*1H;/q;;;;+2/p-2

Clé InChI

KDADQDWVKZJTDQ-UHFFFAOYSA-L

Description générale

cis-Dichlorobis(dimethyl sulfoxide)platinum(II) is a platinum complex used as a catalyst in various chemical reactions, including the methylation of polyfluorinated aryl imines and methane oxidation. It is identified as an effective C-F activation precatalyst.

Application

cis-Dichlorobis(dimethyl sulfoxide)platinum(II) can be used as a:
  • Catalyst in the oleum-mediated (SO3-H2SO4) methane oxidation to form methyl bisulfate (MBS).
  • Precursor in the synthesis of cyclometalated complexes.

Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

R S Dewoskin et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 9(4), 529-537 (1993-07-01)
The effects of hyperthermia (HY) on cisplatin (CDDP) nephrotoxicity and kidney metal concentrations were evaluated in female F344 rats. Rats were anaesthetized with a xylazine/ketamine mixture, heated on a water-bed for 1 h to an intraperitoneal temperature of 41.1 +/-
A W Konings et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 9(4), 553-562 (1993-07-01)
cDDP-resistant Ehrlich ascites tumour (EAT) cells (ER cells) were tested for cellular content of total glutathione, heat sensitivity, cDDP sensitivity and synergistic effects of a combined treatment of heat and chemotherapy. In comparison with the non-resistant EAT cells (EN) the
H Nakagawa et al.
Journal of neuro-oncology, 16(1), 69-76 (1993-04-01)
Parenchymal brain tumors, which were metastases of primary lung cancer, were surgically removed from 25 patients. During the operation, patients were administered (intravenous or intracarotid) 100 mg/sq m of cis-diamminedichloroplatinum (CDDP) and postoperatively, they received intravenous CDDP at 3-month intervals
K Isshiki et al.
Journal of surgical oncology, 52(1), 21-25 (1993-01-01)
In hepatocellular carcinoma cell lines, the intensity of staining with the monoclonal antibody C-219 to the multidrug-resistant gene (mdr1) product P-glycoprotein and the intensity of the band at a molecular weight of 170 KDa on Western blot were associated closely
J A Gondal et al.
European journal of cancer (Oxford, England : 1990), 29A(11), 1536-1542 (1993-01-01)
The systemic toxicity and efficacy of cisplatin (CDDP) were examined in vitro and in vivo. Procedures were performed before and after the antineoplastic agent was encapsulated into multilamellar liposomes (L-CDDP). In vitro cytotoxicity evaluation in L1210 murine leukaemia and NIH

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