764779

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)

PEG average M_n 2,000, PDLLA average M_n 2,000

• Synonyme(s) : PEG-PDLLA
• Code UNSPSC : 12162002
• Nomenclature NACRES : NA.23

Propriétés

• Description: n=45, m=28 (typical); typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)
• Niveau de qualité: 100
• Forme: pellets
• Poids mol.: PDLLA average M_n 2,000; PEG average M_n 2,000; average M_n 4,000 (total)
• Intervalle de dégradation: 2-4 weeks
• Température de transition: T_g 11 °C (PEG block); T_m 244-248 °C; T_g 88 °C (PDLLA block)
• PDI: ≤1.4
• Température de stockage: 2-8°C

Description

Description générale

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.

Application

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

water-solubilization of drugs

Caractéristiques et avantages

• Good biocompatibility, low immunogenicity and good degradability.
• Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable