556815

3-Ethyl-4-methyl-3-pyrrolin-2-one

97%

• Formule empirique (notation de Hill): C₇H₁₁NO
• Numéro CAS: 766-36-9
• Poids moléculaire : 125.17
• Numéro MDL: MFCD00173861
• Code UNSPSC : 12352100
• ID de substance PubChem : 24879585
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Pureté: 97%
• Pf: 100-104 °C (lit.)
• Chaîne SMILES: CCC1=C(C)CNC1=O
• InChI: 1S/C7H11NO/c1-3-6-5(2)4-8-7(6)9/h3-4H2,1-2H3,(H,8,9)
• Clé InChI: YCTNTSVMJWIYTQ-UHFFFAOYSA-N

Description

Description générale

3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:

• allylamine, via palladium(II)-assisted cyclization
• 4-methoxybenzylamine, via a ring-closing-metathesis strategy
• 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one

Application

3-Ethyl-4-methyl-3-pyrrolin-2-one (3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one) may be employed as a precursor for the synthesis of glimepiride (antidiabetic drug) and its derivatives (sulfonylurea drugs). It may also be employed for the preparation of 2-ethyl-3-methyl-(10H)-
dipyrrin-1-one.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)