536822
PAMAM-OH dendrimer, generation 6 solution
5 wt. % in methanol
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About This Item
Formule linéaire :
[NH2(CH2)2NH2]:(G=6);dendri PAMAM(NHCH2CH2OH)256
Poids moléculaire :
58298.21
Numéro MDL:
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.25
Produits recommandés
Description
amidoethanol surface groups
Niveau de qualité
Forme
liquid
Poids mol.
generation 6
Caractéristiques
core type ethylenediamine core (2-carbon core)
Concentration
5 wt. % in methanol
Nb de groupes de surface
256
Indice de réfraction
n20/D 1.336
Densité
0.807 g/mL at 25 °C
Température de stockage
2-8°C
Description générale
PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.
Application
PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.
Forme physique
Contains 256 surface hydroxyl groups.
Informations légales
Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Organes cibles
Eyes
Code de la classe de stockage
3 - Flammable liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
51.8 °F - closed cup
Point d'éclair (°C)
11 °C - closed cup
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Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)
Polyamidoamine dendrimers for enhanced solubility of small molecules and other desirable properties for site-specific delivery: Insights from experimental and computational studies
Shadrack DM, et al.
Molecules (Basel), 23(6), 1419-1419 (2018)
Synthesis and characterization of Cu, Ag and Au dendrimer-encapsulated nanoparticles and their application in the reduction of 4-nitrophenol to 4-aminophenol
Nemanashi M and Meijboom R
Journal of Colloid and Interface Science, 389(1), 260-267 (2013)
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