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536709

Sigma-Aldrich

PAMAM dendrimer, ethylenediamine core, generation 5.0 solution

5 wt. % in methanol

Synonyme(s) :

Poly(amidoamine)

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About This Item

Formule linéaire :
[NH2(CH2)2NH2]:(G=5);dendri PAMAM(NH2)128
Numéro CAS:
163442-68-0
Poids moléculaire :
28824.81
Numéro MDL:
MFCD00197936
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Description

amino surface groups

Niveau de qualité

100

Forme

liquid

Poids mol.

generation 5.0

Caractéristiques

core type ethylenediamine core (2-carbon core)

Concentration

5 wt. % in methanol

Nb de groupes de surface

128

Densité

0.797 g/mL at 25 °C

Température de stockage

2-8°C

Description générale

PAMAM dendrimers are water-soluble, non-immunogenic, and biocompatible symmetrical polymers. They possess a large quantity of modifiable terminal functional groups that can bind to various targeting or guest molecules. These terminal groups are used to covalently attach drugs, targeting ligands, or imaging agents for targeted delivery, controlled release, or imaging applications.

Application


  • Synthesis of beta-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: This study presents an alternative to the ethylenediamine core in PAMAM dendrimers, using an EDTA core instead, providing insights into modifications that affect the dendrimers properties (Gonzalez Mendez et al., 2022).

  • New Advances in General Biomedical Applications of PAMAM Dendrimers: Discusses the composition variations of PAMAM dendrimer cores, including ethylenediamine, and their implications on biomedical applications (Araujo et al., 2018).

  • Poly (amidoamine) Dendrimers: Covalent and Supramolecular Synthesis: This paper reviews various synthetic strategies for PAMAM dendrimers, emphasizing the role of the ethylenediamine core in their structural formation (Lyu et al., 2019).

  • Modified Carboxyl-Terminated PAMAM Dendrimers as a Cytocompatible Nano Based Drug Delivery System: Examines the biocompatibility and drug delivery efficiency of modified PAMAM dendrimers, highlighting the cores critical role (Vu et al., 2019).

  • Use of Polyaminoamide Dendrimers Starting from Different Core-Initial Molecules for Inhibition of Silica Scale: This study explores the use of ethylenediamine-core PAMAM dendrimers in industrial applications, particularly for silica scale inhibition (Sun et al., 2021).

Forme physique

Contains 128 surface primary amino groups.

Informations légales

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

49.5 °F - closed cup - Methanol

Point d'éclair (°C)

9.7 °C - closed cup - Methanol

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Certificats d'analyse (COA)

Lot/Batch Number
MKCS4366
MKCW0116
MKCW1574
MKCT8478
MKCT3296

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Catriona H Edwards et al.
Scientific reports, 10(1), 12422-12422 (2020-07-28)
In this study, the use of dendrimer-coated carbon nanotubes (CNTs) as a delivery vehicle for dsRNA was assessed in Tribolium castaneum. Exposure to low dosages of polyamidoamine dendrimer carbon nanotubes (PAMAM-CNTs) did not affect T. castaneum larval mortality. Expression of
The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine
Bharathi Devarakonda, et al.
International Journal of Pharmaceutics, 284, 133-140 (2004)
Roberta Risoluti et al.
Journal of pharmaceutical analysis, 10(4), 351-355 (2020-09-15)
In this work, functionalized carbon nanotubes (CNTs) using two polyamine polymers, polyethyleneimine (PEI) and polyamidoamine dendrimer (PAMAM), were investigated by thermal analysis in order to address preparation strategies to obtain low cytotoxic compounds with the ability to conjugate microRNAs and
Drug release characteristics of PAMAM dendrimer?drug conjugates with different linkers
Yunus E. Kurtoglu, et al.
International Journal of Pharmaceutics, 384, 189-194 (2010)
Zhao-Jun Liu et al.
PloS one, 11(4), e0154053-e0154053 (2016-04-23)
Stem cell therapy has emerged as a promising approach for treatment of a number of diseases, including delayed and non-healing wounds. However, targeted systemic delivery of therapeutic cells to the dysfunctional tissues remains one formidable challenge. Herein, we present a

Articles

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Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.

Solubility Enhancement with Dendrimers

Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.

Solubility Enhancement with Dendrimers

Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.

Solubility Enhancement with Dendrimers

Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.

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