391263

2-Dimethylaminoethanol

purified by redistillation, ≥99.5%

• Synonyme(s) : N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine, Jeffcat DMEA
• Formule linéaire : (CH₃)₂NCH₂CH₂OH
• Numéro CAS: 108-01-0
• Poids moléculaire : 89.14
• Numéro Beilstein : 1209235
• Numéro CE : 203-542-8
• Numéro MDL: MFCD00002846
• Code UNSPSC : 12352100
• ID de substance PubChem : 24864369
• Nomenclature NACRES : NA.22

Propriétés

• Pression de vapeur: 100 mmHg ( 55 °C); 6.12 mmHg ( 20 °C)
• Pureté: ≥99.5%
• Forme: liquid
• Produit purifié par: redistillation
• Indice de réfraction: n20/D 1.4294 (lit.)
• Point d'ébullition: 134-136 °C (lit.)
• Pf: −70 °C (lit.)
• Solubilité: alcohol: miscible(lit.); water: soluble
• Densité: 0.886 g/mL at 20 °C (lit.)
• Groupe fonctionnel: amine; hydroxyl
• Chaîne SMILES: CN(C)CCO
• InChI: 1S/C4H11NO/c1-5(2)3-4-6/h6H,3-4H2,1-2H3
• Clé InChI: UEEJHVSXFDXPFK-UHFFFAOYSA-N

Description

Description générale

2-Dimethylaminoethanol (DMAE/deanol) is an amino alcohol. It is the main product formed during the amination of ethylene glycol by dimethylamine on alumina supported copper in a continuous fixed-bed reactor. DMAE has been reported to be the putative precursor of acetylcholine. Its effect as a skin-firming and anti-wrinkle agent has been studied. Microwave spectrum of 2-dimethylaminoethanol has been investigated. Its effect as an organic additive on deposition and anti-reflective properties of porous CaF₂ has been studied. Removal of the benzyl ester groups by transesterification with 2-dimethylaminoethanol from benzyl protected tripeptides has been reported.

Application

2-Dimethylaminoethanol (deanol) may be used as a ligand in the copper-catalyzed amination of aryl bromides and iodides.
2-Dimethylaminoethanol (deanol, DMAE, DMEA) may be used in the synthesis of the following:

• cis -[Co(sac)₂(dmea)₂] and cis -[Zn(sac)₂(dmea)₂] (sac=saccharinate)
• heterotrinuclear complex [Cu₂Zn(NH₃)I₃(Me₂Ea)₃ (HMe₂Ea=2-dimethylaminoethanol)
• 2-alkoxy-N,N-dimethylethylamine
• mixed-metal complexes of copper(II) and lead(II)

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H226,H302 + H312,H314,H331,H335
• Conseils de prudence: P210 - P280 - P301 + P312 + P330 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 + P310
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 104.0 °F - Seta closed cup
• Point d'éclair (°C): 40 °C - Seta closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter