This material can be dissolved in dimethyl sulfoxide (DMSO) at a concentration of 5 mg/mL, with warming. Case C25246106 mentioned it can also be dissolved in a solution containing 1% DMSO, 30% polyethylene glycol, and 1% Tween 80 at the same concentration of 5 mg/mL.
SML1312
Mubritinib
≥98% (HPLC)
Synonym(s):
(E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole, 1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole, CID 6444692, TAK 165, TAK-165
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About This Item
Empirical Formula (Hill Notation):
C25H23F3N4O2
CAS Number:
Molecular Weight:
468.47
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
FC(F)(F)C1=CC=C(/C=C/C2=NC(COC3=CC=C(C=C3)CCCCN4C=CN=N4)=CO2)C=C1
InChI
1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
InChI key
ZTFBIUXIQYRUNT-MDWZMJQESA-N
Gene Information
human ... ERBB2(2064)
Biochem/physiol Actions
Mubritinib (TAK-165) is a potent and selective inhibitor of ErbB-2 (HER2).
Mubritinib (TAK-165) is a potent and selective inhibitor of the human epidermal growth factor receptor 2 ErbB (HER2) tyrosine kinase. Mubritinib potently inhibits proliferation of cancer cell lines over- expressing ErbB2.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Oxana V Denisova et al.
Scientific reports, 12(1), 13796-13796 (2022-08-14)
Therapeutic resistance to kinase inhibitors constitutes a major unresolved clinical challenge in cancer and especially in glioblastoma. Multi-kinase inhibitors may be used for simultaneous targeting of multiple target kinases and thereby potentially overcome kinase inhibitor resistance. However, in most cases
Ravi Holani et al.
Gut microbes, 12(1), 1785802-1785802 (2020-07-14)
We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with LPS to facilitate its internalization and signaling via endosomic TLR4 in colonic epithelium, evoking synthesis of the human
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What solvents are recommended for dissolving Mubritinib (SML1312) for in vivo experiments?
1 answer-
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what solvents should be used to dissolve Mubritinib (SML1312) for in vivo experiments.
1 answer-
This material can be dissolved in dimethyl sulfoxide (DMSO) at 5 mg/mL, with warming.
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