R103

Ritanserin

powder

• Synonym(s): 6-[2-[4-(bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
• Empirical Formula (Hill Notation): C₂₇H₂₅F₂N₃OS
• CAS Number: 87051-43-2
• Molecular Weight: 477.57
• MDL number: MFCD00069341
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278117
• NACRES: NA.77

Properties

• form: powder
• color: white
• solubility: methanol: >10 mg/mL; DMSO: >10.1 mg/mL; 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble; dilute aqueous base: insoluble
• SMILES string: CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
• InChI: 1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
• InChI key: JUQLTPCYUFPYKE-UHFFFAOYSA-N
• Gene Information: human ... HTR2A(3356) ; rat ... Adra1a(29412) , Drd2(24318) , Htr1a(24473) , Htr2a(29595) , Htr7(65032)

Description

Application

Ritanserin has been used in behavioral testing and as a serotonin 2A receptor (5-HT2A)-receptor antagonist.

Biochem/physiol Actions

Potent 5-HT_2A serotonin receptor antagonist/inverse agonist that crosses the blood-brain barrier.

Ritanserin is a potent serotonin 2A receptor (5-HT2A) serotonin receptor antagonist/inverse agonist, which crosses the blood-brain barrier. It modulates 5-HT2A receptors and has been suggested to have antiparkinsonian effect. Ritanserin also impacts schizophrenia by modulating mood, cognition and negative symptoms.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves