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C7821

Sigma-Aldrich

Curdlan

from Alcaligenes faecalis, ≥98% (TLC), solid

Synonym(s):

β-1,3-Glucan hydrate

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About This Item

CAS Number:
54724-00-4
MDL number:
MFCD00212920
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Curdlan from Alcaligenes faecalis,

form

solid

Quality Level

200

storage temp.

2-8°C

General description

Curdlan is an insoluble natural polymer with linear structure mainly produced by Alcaligenes faecalis. It is a dietary fiber with gelatin properties.

Application

Curdlan from Alcaligenes faecalis has been used:
  • for the stimulation of carp macrophages for regulation of differentially expressed genes
  • to stimulate human intestinal epithelial cells for cytokine secretion
  • to study its effect on transcriptional responses of inflammation/respiratory burst-associated genes in mouse alveolar macrophages by customized reverse transcription (RT)-PCR based arrays
  • as a substrate in β-1,3–1,4-Glucanase activity assay

Biochem/physiol Actions

Curdlan is used as a food additive in the food industry. It improves the elasticity and reduces the embrittling tendency of hydroxyapatite/chitosan scaffold, which aids in bone regeneration.
Curdlan is a (1,3)-β-glucan. It is a pathogen-associated molecular-pattern (PAMP) recognized by the receptor dectin-1. Activation of dectin-1, together with TLR2/TLR6, promotes signaling resulting in the production of pro-inflammatory cytokines, thus inducing inflammation.

Preparation Note

For gelation at 70 °C, the concentration of the sodium hydroxide should be 0.01 M.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Microbial exopolisaccharides for biomedical applications
Journal of Material Science & Engineering, 165-219 (2019)
Characterisation of a novel Bacillus sp. SJ-10 I?-1,3-1,4-glucanase isolated from jeotgal, a traditional Korean fermented fish.
Kim, et al.
Bioprocess and Biosystems Engineering, 36, 721-727 (2013)
Chunju An et al.
The Journal of biological chemistry, 284(29), 19716-19726 (2009-06-03)
Serine proteinases in insect plasma have been implicated in two types of immune responses; that is, activation of prophenoloxidase (proPO) and activation of cytokine-like proteins. We have identified more than 20 serine proteinases in hemolymph of the tobacco hornworm, Manduca
Jules Petit et al.
Frontiers in immunology, 10, 280-280 (2019-03-14)
Immune-modulatory effects of β-glucans are generally considered beneficial to fish health. Despite the frequent application of β-glucans in aquaculture practice, the exact receptors and downstream signalling remains to be described for fish. In mammals, Dectin-1 is a member of the
K N Masihi et al.
International journal of immunopharmacology, 19(9-10), 463-468 (1998-06-24)
The effects of glucan-based immunomodulators curdlan sulfate (CRDS) and lentinan on cytokine production stimulated by lipopolysaccharide (LPS) in bacillus Calmette-Guerin (BCG)-primed mice were investigated. Pretreatment with CRDS or lentinan before LPS administration induced a striking inhibition of up to 89%
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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