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P5288

Sigma-Aldrich

Polyvinylpyrrolidone

for molecular biology, nucleic acid hybridization tested, mol wt 360,000

Synonym(s):

PVP, Polyvidone, Povidone

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About This Item

Linear Formula:
(C6H9NO)n
CAS Number:
9003-39-8
MDL number:
MFCD00149016
UNSPSC Code:
12161700
PubChem Substance ID:
24898616
NACRES:
NA.25
Pricing and availability is not currently available.

grade

for molecular biology

Quality Level

200

form

powder

mol wt

360,000

suitability

nucleic acid hybridization tested

foreign activity

Endonuclease, exonuclease, RNase, none detected

SMILES string

C=CN1CCCC1=O

InChI

1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

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General description

Polyvinylpyrrolidone is a large polymer containing a carbonyl, C-N and alkyl functional groups.[1]

Application

Polyvinylpyrrolidone has been used:
  • to perform intracytoplasmic sperm injection procedure[2]
  • in the preparation of endophyte coating agent mixture, to coat creeping bentgrass seed[3]
  • as a component of prehybridization solution[3]

Biochem/physiol Actions

Polyvinylpyrrolidone can bind to polyphenol. Thus, it is known to be used for RNA isolation from plants rich in polyphenols.[4] It is extensively used in the synthesis of nanoparticles.[1]

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000398974
0000374165
0000374166
0000367885
0000365939

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Blastocyst formation in in vitro fertilization versus intracytoplasmic sperm injection cycles: influence of the fertilization procedure
Van LL, et al.
Fertility and Sterility, 83(5), 1397-1403 (2005)
Relevance of in vitro agar based screens to characterize the anti-fungal activities of bacterial endophyte communities
Shehata HR, et al.
BMC Microbiology, 16(1), 8-8 (2016)
Inclusion of polyvinylpyrrolidone in the polymerase chain reaction reverses the inhibitory effects of polyphenolic contamination of RNA
Koonjul PK, et al.
Nucleic Acids Research, 27(3), 915-916 (1999)
Jan Konietzka et al.
Current biology : CB, 30(1), 1-16 (2019-12-17)
Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active neurons are under the control of homeostatic mechanisms that determine sleep need. However, little is known about the molecular and circuit mechanisms that translate sleep need into the depolarization
Kallum M Koczkur et al.
Dalton transactions (Cambridge, England : 2003), 44(41), 17883-17905 (2015-10-06)
Colloidal synthesis offers a route to nanoparticles (NPs) with controlled composition and structural features. This Perspective describes the use of polyvinylpyrrolidone (PVP) to obtain such nanostructures. PVP can serve as a surface stabilizer, growth modifier, nanoparticle dispersant, and reducing agent.
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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