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C2970000

Crotamiton

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N-Ethyl-o-crotonotoluidide, N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton

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About This Item

Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
483-63-6
Molecular Weight:
203.28
MDL number:
MFCD00026989
UNSPSC Code:
41116107
PubChem Substance ID:
329775015
NACRES:
NA.24

grade

pharmaceutical primary standard

description

predominantly trans

API family

crotamiton

manufacturer/tradename

EDQM

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

density

0.987 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Crotamiton EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

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Maria Wesołowska et al.
Wiadomosci parazytologiczne, 51(3), 253-256 (2006-08-18)
Demodex mites are common parasites in the hair follicles and in the pilosebaceous glands. Demodex folliculorum and D. brevis have been identified in humans and play a role in three facial conditions: Pityriasis folliculorum, rosacea-like demodicidosis and Demodicidosis gravis. The
Rika Sekine et al.
Experimental dermatology, 21(3), 201-204 (2012-03-03)
Itch accompanies various skin diseases. As a number of mediators other than histamine can be involved in the itch sensation, H1 receptor antagonists are not necessarily effective in treating itch. External application of antipruritic drugs is occasionally used as an
E Dika et al.
Cutaneous and ocular toxicology, 25(3), 211-216 (2006-09-19)
Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose
Ahmed M Al-Arfaj et al.
The American journal of tropical medicine and hygiene, 76(5), 967-971 (2007-05-10)
A 31-year-old Saudi man was seen at an ear, nose, and throat clinic at Riyadh, Saudi Arabia, with bilateral itching in the external auditory canal. On otoscopic examination, the skin lining the ear canal was thickened with whitish sheets of
F Forton et al.
The British journal of dermatology, 138(3), 461-466 (1998-05-15)
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical
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