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66930

Sigma-Aldrich

N-Methyl-D-glucamine

ReagentPlus®, ≥99.0% (T)

Synonym(s):

1-Deoxy-1-(methylamino)-D-glucitol, Meglumine

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About This Item

Empirical Formula (Hill Notation):
C7H17NO5
CAS Number:
6284-40-8
Molecular Weight:
195.21
Beilstein:
385906
EC Number:
228-506-9
MDL number:
MFCD00004707
UNSPSC Code:
12352104
PubChem Substance ID:
329760336
NACRES:
NA.22
Pricing and availability is not currently available.

biological source

synthetic

Quality Level

200

product line

ReagentPlus®

Assay

≥99.0% (T)

form

powder

optical activity

[α]20/D −16.5±0.5°, c = 2% in H2O

autoignition temp.

~662 °F

mp

126-131 °C
129-131.5 °C (lit.)

solubility

H2O: 0.1 g/mL, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
phosphate (PO43-): ≤5 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤20 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1

InChI key

MBBZMMPHUWSWHV-BDVNFPICSA-N

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General description

N-Methyl-D-glucamine, also known as Meglumine, is a sorbitol-derived amino sugar. It acts as a catalyst in one-pot synthesis of pyranopyrazole derivatives.[1]

Application

N-Methyl-D-glucamine is utilized as:
  • An ion exchange resin due to its high affinity and selectivity for specific ions[2]
  • A buffering agent to remove boron from an aqueous solution[3]

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
WXBF4959V
WXBF2928V
WXBF2929V
WXBF2930V
WXBF4291V

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Water-insoluble polymer?clay nanocomposite ion exchange resin based on N-methyl-D-glucamine ligand groups for arsenic removal.
Urbano BF
Reactive functional Polymers, 72(9), 642-649 (2012)
Polymeric microspheres with N-methyl-d-glucamine ligands for boron removal from water solution by adsorption?membrane filtration process.
Wolska J
Environmental Geochemistry and Health, 32(4), 349-352 (2010)
Synthesis of graft adsorbent with N-methyl-D-glucamine for boron adsorption.
Hoshina H
Journal of ion exchange, 18(4), 236-239 (2007)
Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis using N-methyl-D-glucamine as an effective electrolyte additive
A Zinellu, et al.
European Journal of Pharmaceutical Sciences, 24, 375-380 (2005)
Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives
RY Guo, et al.
Tetrahedron, 69, 9931-9938 (2013)
View All Related Papers

Questions

1–2 of 2 Questions  

  1. What is the optimal volume of HCl to use in order to achieve a pH of 7.3 when using N-Methyl-D-glucamine (P/N: 66930) in a patch clamp solution without adding any additional Na+ ions?

    1 answer

    1. To neutralize 0.5 L of 120 mM 66930 solution, it is recommended to use 8 ml of 0.5 N HCl to adjust the pH to 8, and then dilute the HCl (e.g. 0.1 N) to titrate to pH 7.3. This approach can help avoid the drastic drop in pH.

      Helpful?

  2. When preparing a solution for patch clamping, what is the best optimal amount of HCL to use for ensuring that NaOH will not be required to maintain pH 7.3? F

    1 answer

    1. The necessary amount of HCl would need to be determined by the end-user. It is recommended to record the initial pH value prior to the addition of HCl. After recording the intial pH, add small increments of HCl (1-2 mL). The molarity of the HCL must also be considered when adding incremental volumes. A 1M HCl would be considered fairly dilute. Higher concentrations would require volume adjustments. Record the pH value after 5 minutes of stirring.

      For further questions or concerns, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

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