880343P
Avanti
PChemsPC
Avanti Research™ - A Croda Brand 880343P, powder
Synonym(s):
1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine
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About This Item
Empirical Formula (Hill Notation):
C55H98NO10P
CAS Number:
Molecular Weight:
964.34
UNSPSC Code:
51191904
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 25 mg (880343P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880343P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=P([O-])(OCC[N+](C)(C)C)OC[C@H](OC(CCC(OC1CC[C@]2(C)C(C1)=CCC3C2CC[C@]4(C)C3CC[C@H]4[C@@H](C)CCCC(C)C)=O)=O)COC(CCCCCCCCCCCCCCC)=O
Application
PChemsPC or 1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine might be used to study its pharmacokinetics and biodistribution patterns in comparison with phospholipid-cholesterol liposomes. It might also be used as a component in the monolayer to study its characterization at the air/water interface.
Biochem/physiol Actions
PChemsPC or 1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine is a sterol-phospholipid hybrid. Cholesterol incorporation with phospholipids reduces the permeability of the lipid bilayer, organizes phospholipid chains and avoids the phospholipid phase transition. This improves the stability of the vesicles.
Packaging
5 mL Amber Glass Screw Cap Vial (880343P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Michał Flasiński et al.
Langmuir : the ACS journal of surfaces and colloids, 32(16), 4095-4102 (2016-04-06)
The two synthetic sterol-phospholipid hybrids DCholPC and PCholPC were investigated in monolayers at the air/water interface. Study was based on π-A isotherm analysis complemented with application of grazing incidence X-ray diffraction. It was found that both compounds are capable of
Aditya G Kohli et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 86-93 (2013-12-26)
We introduce a method for tracking the rate and extent of delivery of liposome contents in vivo based on encapsulation of 4-methylumbelliferyl phosphate (MU-P), a profluorophore of 4-methylumbelliferone (MU). MU-P is rapidly dephosphorylated by endogenous phosphatases in vivo to form
F Foglia et al.
Langmuir : the ACS journal of surfaces and colloids, 27(13), 8275-8281 (2011-06-04)
Langmuir isotherm, neutron reflectivity, and small angle neutron scattering studies have been conducted to characterize the monolayers and vesicular bilayers formed by a novel chimeric phospholipid, ChemPPC, that incorporates a cholesteryl moeity and a C-16 aliphatic chain, each covalently linked
Zhaohua Huang et al.
Angewandte Chemie (International ed. in English), 48(23), 4146-4149 (2009-05-09)
Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the
Maryam Iman et al.
International journal of pharmaceutics, 408(1-2), 163-172 (2011-02-01)
1,2-Di-stigma-steryl-hemi-succinoyl-sn-glycero-3-phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Since amphotericin B (AmB) interacts with sterols, we postulated that DSHemsPC could be used in
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