Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML1195

Sigma-Aldrich

Palonosetron hydrochloride

≥98% (HPLC)

Synonym(s):

(3aS)-2-[(3S)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride, (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-Benz[de]isoquinolin-1-one hydrochloride (1:1), RS 25259-197

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H24N2O · HCl
CAS Number:
135729-62-3
Molecular Weight:
332.87
MDL number:
MFCD00939524
UNSPSC Code:
12352200
PubChem Substance ID:
329825713
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -90 to -110°, c = 0.4 in H2O

storage condition

desiccated
protect from light

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1N([C@H]2C3CCN(CC3)C2)C[C@]4([H])C5=C1C=CC=C5CCC4.[H]Cl

InChI

1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1

InChI key

OLDRWYVIKMSFFB-SSPJITILSA-N

Gene Information

human ... HTR3A(3359)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Palonosetron is a potent and selective 5-HT3 receptor antagonist (Aloxi) used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
Palonosetron is a potent and selective 5-HT3 receptor antagonist.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
025M4743V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jing Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13560-13571 (2019-10-02)
So far, a comprehensive animal model that can mimic both the central and peripheral pathophysiological changes of irritable bowel syndrome (IBS) is lacking. Here, we developed a novel IBS rat model combining trinitro-benzene-sulfonic acid (TNBS) and chronic unpredictable mild stress

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service