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S3134

Sigma-Aldrich

Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)

lyophilized powder, ≥2,000 units/mg solid

Synonym(s):

Streptokinase from Streptococcus hemolyticus

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About This Item

CAS Number:
9002-01-1
Enzyme Commission number:
3.4.99.0 (BRENDA, IUBMB)
EC Number:
232-647-1
MDL number:
MFCD00082037
UNSPSC Code:
12352204
eCl@ss:
32160410
NACRES:
NA.54

form

lyophilized powder

specific activity

≥2,000 units/mg solid

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)

InChI key

XRZWVSXEDRYQGC-UHFFFAOYSA-N

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General description

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

Application

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

Biochem/physiol Actions

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

Unit Definition

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

Physical form

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Streptokinase--a clinically useful thrombolytic agent
Banerjee A, et al.
Biotechnology Advances, 22(4), 2004-2004 (2004)
Streptokinase--a clinically useful thrombolytic agent
Banerjee A, et al.
Biotechnology Advances, 22(4), 287-307 (2004)
Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?
D Collen et al.
Blood, 84(3), 680-686 (1994-08-01)
Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture
Nikandrov, V., et al.
Biomeditsinskaia Khimiia, 54, 192-200 (2012)
Ansar S Zhalyalov et al.
PloS one, 12(7), e0180668-e0180668 (2017-07-08)
Fibrinolysis is a cascade of proteolytic reactions occurring in blood and soft tissues, which functions to disintegrate fibrin clots when they are no more needed. In order to elucidate its regulation in space and time, fibrinolysis was investigated using an
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