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Key Documents

A8937

Sigma-Aldrich

Adenosine 5′-triphosphate dipotassium salt hydrate

from microbial, ≥92% (HPLC)

Synonym(s):

ATP, 5′-ATP-K2

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About This Item

Empirical Formula (Hill Notation):
C10H14K2N5O13P3 · xH2O
CAS Number:
Molecular Weight:
583.36 (anhydrous basis)
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51

biological source

microbial

Assay

≥92% (HPLC)

form

powder

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

[K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

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General description

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:
  • in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
  • as a component of energy solution for calibrating crude cell extract
  • to test its dependency with PK11195 in mediating autophagy

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems.

Caution

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP
Johnson TA, et al.
Frontiers in Pharmacology, 10, 98-98 (2019)
Ca2+-dependent autophagy is enhanced by the pharmacological agent PK11195
Gastaldello A, et al.
Autophagy, 6(5), 607-613 (2010)
RNA-protein UV-crosslinking Assay
Poria DK and Ray PS
Bio-protocol, 7(6), e2193-e2193 (2017)
A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding
Frezza E, et al.
PLoS ONE, 13(4), e0196207-e0196207 (2018)
ATP synthesis and storage
Bonora M, et al.
Purinergic Signaling, 8, 343-357 (2012)

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