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Supelco

4,4′-Methylene-bis(2-methylaniline)

analytical standard

Synonym(s):

4,4′-Diamino-3,3′-dimethyldiphenylmethane, 4,4′-Methylene-di(o-toluidine)

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About This Item

Empirical Formula (Hill Notation):
C15H18N2
CAS Number:
Molecular Weight:
226.32
Beilstein:
398069
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

Cc1cc(Cc2ccc(N)c(C)c2)ccc1N

InChI

1S/C15H18N2/c1-10-7-12(3-5-14(10)16)9-13-4-6-15(17)11(2)8-13/h3-8H,9,16-17H2,1-2H3

InChI key

WECDUOXQLAIPQW-UHFFFAOYSA-N

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General description

4,4′-Methylene-bis(2-methylaniline) belongs to the primary aromatic amines (PAAs) family of compounds which are toxic in nature and are probable human carcinogens.

Application

4,4′-Methylene-bis(2-methylaniline) has been used as a reference standard for the determination of 4,4′-methylene-bis(2-methylaniline) in plastic multilayer food packaging materials by liquid chromatography (LC)-Orbitrap-full scan-high resolution mass spectrometry (HRMS).
It may be used as a reference standard for the analysis of 4,4′-methylene-bis(2-methylaniline) in dyes, cosmetics, finger paints and inks for pens and tattoos by LC-MS.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Caution

Restricted to professional users. Attention − Avoid exposure − obtain special instructions before use.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Liquid chromatography-full scan-high resolution mass spectrometry-based method towards the comprehensive analysis of migration of primary aromatic amines from food packaging..
Mattarozzi,et al.
Journal of Chromatography A, 1320, 96-102 (2013)
A survey of techniques for estimating and monitoring aromatic amines of major industrial importance.
L Fishbein
IARC scientific publications, (40)(40), 75-105 (1981-01-01)
Aromatic amines of major industrial importance: use and occurrence.
L Fishbein
IARC scientific publications, (40)(40), 51-74 (1981-01-01)
The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man.
G F Rubino et al.
Environmental research, 27(2), 241-254 (1982-04-01)
Development of LC/MS/MS Method for Screening and Quantitation of 47 Synthetic Dyes under Restricted Substance List in Textiles..
Chew,et al.
Mitteilungen aus Lebensmitteluntersuchung und Hygiene (2016)

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