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U5632

Sigma-Aldrich

Ubiquitin−Agarose

saline suspension

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
41106500
NACRES:
NA.56

form

saline suspension

Quality Level

extent of labeling

7-15 mg per mL

technique(s)

affinity chromatography: suitable

matrix

Fast flow highly cross-linked 4% beaded agarose

matrix spacer

6 carbon

storage temp.

2-8°C

Application

Ubiquitin-agarose is used in affinity chromatography, protein chromatography, intracellular protein degradation, calpain and lysosomal proteases, proteomics, specialty resins and ubiquitination analysis. Ubiquitin-agarose has been used in a study to produce evidence for a particulate location of ubiquitin conjugates and ubiquitin-conjugating enzymes in the rabbit brain. Ubiquitin-agarose has also been used to study fertilization of the ascidian, Halocynthia roretzi.

Physical form

Suspension in 1 M NaCl containing 15 Mm Sodium azide.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Ciechanover et al.
The Journal of biological chemistry, 257(5), 2537-2542 (1982-03-10)
We have previously described an enzyme that activates ubiquitin, the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes (Ciechanover, A., Heller, H., Katz-Etzion, R., and Hershko, A. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 761-765). It carries
M Majetschak et al.
European journal of biochemistry, 255(2), 482-491 (1998-08-26)
Ubiquitin is often implicated as a specific tag for protein degradation via the ubiquitin system although only a limited number of physiological proteins have been shown to be degraded in their native tissues via this pathway in vivo. Ubiquitin may
Shin-Chung Kang et al.
The Journal of pathology, 203(1), 603-608 (2004-04-20)
Although the key event in the pathology of prion diseases is thought to be the conversion of cellular prion protein (PrP(C)) to the protease-resistant scrapie species termed PrP(Sc), the factors that contribute to neurodegeneration in scrapie-infected animals are poorly understood.
Anjali Joshi et al.
Traffic (Copenhagen, Denmark), 9(11), 1972-1983 (2008-09-27)
Retroviral Gag polyprotein precursors are both necessary and sufficient for the assembly and release of virus-like particles (VLPs) from infected cells. It is well established that small Gag-encoded motifs, known as late domains, promote particle release by interacting with components
Hyoung Tae Kim et al.
Methods in molecular biology (Clifton, N.J.), 832, 639-652 (2012-02-22)
The biological role and fates of ubiquitin (Ub) conjugates are determined by the nature of the ubiquitin chain formed on the protein. Recently, we reported that Ring-finger and U-box ubiquitin ligases (E3s), when functioning with different E2s, synthesize different types

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