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SML3727

Sigma-Aldrich

WIC1

≥98% (HPLC)

Synonym(s):

N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide, Wnt Inhibitor Compound 1

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About This Item

Empirical Formula (Hill Notation):
C22H23N3O3
CAS Number:
943083-58-7
Molecular Weight:
377.44
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow to brown

solubility

DMSO:methanol (1:1): 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

O=C1OC2=C(C=C1C(NC3=CC=C(N4CCN(CC4)CC)C=C3)=O)C=CC=C2

Biochem/physiol Actions

WIC1 is a potent Wnt/β-catenin signaling inhibitor (IC50 = 10 nM against 24h 5 μM CHIR-induced BEAS2B TCF/LEF reporter activity) that reduces airway basal stem cell (ABSC) proliferation (92% reduction of 4d 2 μM CHIR-induced hABSC proliferation by 1 μM WIC1) and induces ciliated cell differentiation (by 1.9-fold on d14 with 100 nM WIC1; mABSCs under air-liquid interface (ALI) condition) by suppressing β-catenin Y489 phosphorylation (complete inhibition of 24h 5 μM CHIR-induced pY489 in BEAS2B by 1 μM WIC1) and TP63 expression (80% reduction of 9d 1 μM CHIR-induced TP63 in mABSC by 1 μM WIC1; 40% reduction of 48h 5 μM CHIR-induced TP63 in BEAS2B by 1 μM WIC1).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Cody J Aros et al.
Cell reports, 30(7), 2055-2064 (2020-02-23)
Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer progression. This led us to develop a model of airway basal

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