SML2409

NITD008

≥98% (HPLC)

• Synonym(s): 7-(2-C-Ethynyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 7-Deaza-2′-C-acetylene-adenosine, NITD 008
• Empirical Formula (Hill Notation): C₁₃H₁₄N₄O₄
• CAS Number: 1044589-82-3
• Molecular Weight: 290.27
• MDL number: MFCD27952796
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@](C#C)3O)O)CO
• InChI: 1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1
• InChI key: NKRAIOQPSBRMOV-NRMKKVEVSA-N

Description

Biochem/physiol Actions

NITD008 is a selective inhibitor of flaviviruses including dengue virus (EC50 = 0.64 μM), hepatitis C virus and Zika virus, and has also been shown to inhibit tick-borne flaviviruses in vitro. NITD008 has been reported to inhibit RNA-dependent RNA polymerase (RdRp), an essential protein of RNA viruses.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable