SML1606

Oseltamivir phosphate

≥98% (HPLC), Neuraminidase inhibitor, powder

• Synonym(s): GS4104, (3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate salt
• Empirical Formula (Hill Notation): C₁₆H₂₈N₂O₄ ·H₃PO₄
• CAS Number: 204255-11-8
• Molecular Weight: 410.40
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825492
• NACRES: NA.77
• MDL number: MFCD08059548
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Oseltamivir phosphate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -26 to -36°, c = 1 in H₂O
• color: white to beige
• solubility: H₂O: 30 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1
• InChI: 1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1
• InChI key: PGZUMBJQJWIWGJ-ONAKXNSWSA-N

Description

Biochem/physiol Actions

Oseltamivir phosphate is an influenza viral neuraminidase inhibitor. Oseltamivir phosphate, an antiviral, is used clinically to treat influenza A and influenza B, and to prevent flu after exposure. Oseltamivir phosphate is hydrolyzed in the liver to its active form, oseltamivir carboxylate, which is an inhibitor of influenza viral neuraminidases essential for viral replication. Oseltamivir has a broad spectrum of activity against a range of influenza A and B subtypes with IC₅₀ values for neuraminidases measured from less than 1 nM to approximately 30 nM, depending on the virus subtype.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317,H319,H412
• pcodes: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable