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SML0922

NSC130813

≥98% (HPLC)

Synonym(s):

4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02

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About This Item

Empirical Formula (Hill Notation):
C26H27ClN4O2 · 3HCl
CAS Number:
1082532-95-3
Molecular Weight:
572.35
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

H2O: 10 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.
NSC130813 is a Xeroderma Pigmentosa Group F (XPF) antagonist, inhibitor of nucleotide excision repair (NER) mechanism.

Other Notes

air sensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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