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SAB1400606

Sigma-Aldrich

Anti-ATAD3A antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-FLJ10709

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATAD3A(55210)

General description

ATAD3A (ATPase family, AAA domain containing 3A) is mapped to human chromosome 1p36.33. The encoded protein is a localized in mitochondrial membrane.

Immunogen

ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein.

Sequence
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS

Biochem/physiol Actions

ATAD3A (ATPase family, AAA domain containing 3A) was originally considered as a tumor-specific antigen. Mutation in ATAD3A is known to cause a delayed development, optic atrophy, axonal neuropathy, hypotonia and hypertrophic cardiomyopathy. ATAD3A is involved in mitochondrial development, organization of nucleoid, translation of protein, cell growth, and cholesterol metabolism. Downregulation of ATAD3A affects the mitochondrial dynamics, prevents proliferation and changes the interaction between mitochondria and the endoplasmic reticulum. Upregulation of the gene is seen in several cancer types. ATAD3A is known to offer resistance against chemotherapy and radiation. It is responsible for the mitochondrial membrane and import vesicle -mediated transport of AIF (apoptosis inducing factor) from the endoplasmic reticulum into mitochondria. Downregulation of ATAD3A promotes autophagy as well as apoptosis in uterine cervical cancer cells, and also reduces the ability to resist the anticancer drugs. ATAD3A serves as a biomarker for the prognosis of glioblastoma multiforme. It is also found to be involved in cancers such as uterine cervical cancer, lung adenocarcinoma and prostate cancer.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Weir-Chiang You et al.
Neuro-oncology, 15(10), 1342-1352 (2013-09-24)
ATPase-family, AAA domain containing 3A (ATAD3A) is located on human chromosome 1p36.33, and high endogenous expression may associate with radio- and chemosensitivity. This study was conducted to investigate the significance of ATAD3A in glioblastoma multiforme (GBM). Clinical significance of ATAD3A
Radha Desai et al.
Brain : a journal of neurology, 140(6), 1595-1610 (2017-05-27)
Although mitochondrial disorders are clinically heterogeneous, they frequently involve the central nervous system and are among the most common neurogenetic disorders. Identifying the causal genes has benefited enormously from advances in high-throughput sequencing technologies; however, once the defect is known
Tamar Harel et al.
American journal of human genetics, 99(4), 831-845 (2016-09-20)
ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane protein implicated in mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. We identified a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing (WES)
Y Teng et al.
Oncogene, 35(3), 333-343 (2015-03-31)
AAA domain containing 3A (ATAD3A) is an integral mitochondrial membrane protein with unknown function, although we now show that high-level expression is associated with poor survival in breast cancer patients. Using a mass spectrometry approach we have demonstrated that ATAD3A

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