P7036

Parathyroid hormone human

≥92% (HPLC), powder

• Synonym(s): PTH, Parathormone
• Empirical Formula (Hill Notation): C₄₀₈H₆₇₄N₁₂₆O₁₂₆S₂
• CAS Number: 68893-82-3
• Molecular Weight: 9424.62
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD00081830
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥92% (HPLC)

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥92% (HPLC)
• form: powder
• composition: Peptide content, ≥70%
• solubility: water: 1 mg/mL, clear, colorless
• UniProt accession no.: P01270
• shipped in: ambient
• storage temp.: −20°C
• Gene Information: human ... PTH(5741)

Description

General description

Parathyroid hormone (PTH) is a circulating hormone secreted from the parathyroid gland. This hormone is synthesized as a pre-pro hormone. PTH is composed of binding regions that have a high affinity to a receptor and functional domains that interact with the receptors to initiate an intracellular signaling cascade.

Application

Parathyroid hormone human has been used to incubate mature human adipocytes.

Biochem/physiol Actions

Parathyroid hormone (PTH) exerts its effects on bone and kidney cells. This hormone plays a role in calcium homeostasis. PTH is secreted from the chief cells of the parathyroid gland in response to low extracellular calcium levels or higher levels of extracellular phosphate. PTH deficiency or excess PTH are associated with hypoparathyroidism and hyperparathyroidism, respectively.

Other Notes

Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-Gln-Arg-Pro-Arg-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asn-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable