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J4829

Sigma-Aldrich

JFD00244

≥98% (HPLC), solid

Synonym(s):

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone

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About This Item

Empirical Formula (Hill Notation):
C30H26N2O4
CAS Number:
96969-83-4
Molecular Weight:
478.54
MDL number:
MFCD00208443
UNSPSC Code:
12352202
PubChem Substance ID:
329815737

Assay

≥98% (HPLC)

form

solid

color

violet

solubility

DMSO: ≥10 mg/mL
H2O: <2 mg/mL

storage temp.

room temp

SMILES string

Oc1ccc(CCNc2ccc(NCCc3ccc(O)cc3)c4C(=O)c5ccccc5C(=O)c24)cc1

InChI

1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2

InChI key

UUJHFIBEJJLZBF-UHFFFAOYSA-N

Biochem/physiol Actions

JFD00244 is a SIRT (sirtuin, human silent information regulator) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anu J Tervo et al.
Journal of medicinal chemistry, 47(25), 6292-6298 (2004-11-30)
Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in the cell cycle. To date, some small molecular inhibitors of
Anu J Tervo et al.
Journal of medicinal chemistry, 49(24), 7239-7241 (2006-11-28)
A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Two of these

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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