I2285

IPA-3

≥95% (HPLC), powder

• Synonym(s): 1,1′-Disulfanediyldinaphthalen-2-ol
• Empirical Formula (Hill Notation): C₂₀H₁₄O₂S₂
• CAS Number: 42521-82-4
• Molecular Weight: 350.45
• NACRES: NA.77
• PubChem Substance ID: 329815364
• UNSPSC Code: 12352200
• MDL number: MFCD00388917
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• color: off-white to yellow
• solubility: DMSO: >20 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
• InChI: 1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
• InChI key: RFAXLXKIAKIUDT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.

IPA-3 is an allosteric inhibitor of Pak1.

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Codes: H318,H410
• Precautionary Statements: P273 - P280 - P305 + P351 + P338 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves