GS38
GST T1-1, Recombinant Rat
Synonym(s):
AI255817: glutathione S-transferase, glutathione S-transferase, theta 1, Gstt1-1
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.26
Recommended Products
biological source
rat
Quality Level
recombinant
expressed in E. coli
Assay
>95% (SDS-PAGE)
form
frozen liquid
specific activity
86.6
mol wt
25 kDa
concentration
1.22 mg/mL
storage temp.
−70°C
Gene Information
rat ... Gstt1(14871)
General description
using spectrophotometric determination of 1,2-epoxy-3(4-nitrophenoxy)propane (ENPP) conjugation with reduced glutathione (5 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Biochem/physiol Actions
Glutathione S-transferase theta 1 (Gstt1) is an enzyme that in rats is encoded by the Gstt1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Storage and Stability
The enzyme should be used by the end-user customer within 1 year of receipt.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Anna-Karin Larsson et al.
Archives of biochemistry and biophysics, 497(1-2), 28-34 (2010-03-10)
Glutathione transferase (GST) displaying enhanced activity with the cytostatic drug 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and structurally related alkylating agents was obtained by molecular evolution. Mutant libraries created by recursive recombination of cDNA coding for human and rodent Theta-class GSTs were heterologously expressed
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