Currently, this peptide is synthetically manufactured. The product has not been tested for use in any specific applications or for the presence of DNA. There are a number of different uses in the field of biochemistry. Please see the link below to review the Peer Reviewed Papers available for this item:
https://www.sigmaaldrich.com/search/g4541?focus=papers&page=1&perpage=30&sort=relevance&term=G4541&type=citation_search
G4541
Gly-Gly-His
≥98% (TLC)
Synonym(s):
Copper-binding peptide
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About This Item
Empirical Formula (Hill Notation):
C10H15N5O4
CAS Number:
Molecular Weight:
269.26
UNSPSC Code:
12352209
NACRES:
NA.26
MDL number:
Pricing and availability is not currently available.
Product Name
Gly-Gly-His,
assay
≥98% (TLC)
Quality Segment
form
solid
color
white
storage temp.
−20°C
SMILES string
[nH]1cnc(c1)CC(NC(=O)CNC(=O)CN)C(=O)O
InChI
1S/C10H15N5O4/c11-2-8(16)13-4-9(17)15-7(10(18)19)1-6-3-12-5-14-6/h3,5,7H,1-2,4,11H2,(H,12,14)(H,13,16)(H,15,17)(H,18,19)
InChI key
PDAWDNVHMUKWJR-UHFFFAOYSA-N
General description
Gly-Gly-His (GGH) tripeptide with carboxyl-terminal histidine residue is hydrophilic.[1]
Application
Gly-Gly-His has been used:
- as a peptide test probe in the hydrophilic interaction liquid chromatography (HILIC) studies[1]
- in the electrochemical modification of back-side contact transducers (BSC) electrodes in copper (Cu2+) sensing studies
- for the fabrication carbon nanotube electrode for detection of Cu2+ ions
Biochem/physiol Actions
Gly-Gly-His (GGH) tripeptide displays the affinity of copper (Cu2+) complexation. These complexes display good skin tolerance and may be useful in wound healing.[2] GGH copper complexes are proposed to reduce tumor necrosis factor α (TNF-α)-based interleukin 6 (IL-6) secretion by in vivo studies with fibroblasts.[2] GGH is used in comparative studies with other imidazole-containing peptides such as carnosine. An area of active application research involves the GGH binding of copper ions.
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This Item | |||
|---|---|---|---|
| form solid | form - | form powder | form powder |
| assay ≥98% (TLC) | assay ≥97% (TLC) | assay ≥98% (TLC) | assay ≥99.0% (NT) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| color white | color - | color white to off-white | color white |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hi, I have some questions regarding GGH (G4541): 1) is it a synthetic peptide? 2) is it used in molecular biology? 3) Is it DNA free? Thank you in advance. Best regards Maryam
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