C3743

CI 976

>98% (HPLC), solid

• Synonym(s): 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
• Empirical Formula (Hill Notation): C₂₃H₃₉NO₄
• CAS Number: 114289-47-3
• Molecular Weight: 393.56
• NACRES: NA.77
• PubChem Substance ID: 329775044
• UNSPSC Code: 51111800
• MDL number: MFCD00869662
• Assay: >98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: >98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL, H₂O: insoluble <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
• InChI: 1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
• InChI key: WAFNZAURAWBNDZ-UHFFFAOYSA-N

Description

Application

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

• to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
• to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
• to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

Biochem/physiol Actions

CI-976 is a potent and specific inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase (ACAT) in vitro.

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

Safety Information

• hcodes: H413
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)