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B6292

GF 109203X hydrochloride

≥95%

Synonym(s):

3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride, Bisindolylmaleimide I hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C25H24N4O2 · HCl
CAS Number:
176504-36-2
Molecular Weight:
448.94
NACRES:
NA.77
PubChem Substance ID:
24891903
UNSPSC Code:
12352200
MDL number:
MFCD00236429
Assay:
≥95%
Form:
solid
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biological source

synthetic (organic)

Quality Segment

200

assay

≥95%

form

solid

solubility

methanol: 10 mg/mL, clear, orange to red

storage temp.

2-8°C

SMILES string

Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15

InChI

1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H

InChI key

XRAMWNCMYJHGGH-UHFFFAOYSA-N

General description

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

Application

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

Biochem/physiol Actions

Inhibitor of protein kinase C; potent inhibitor of GSK-3.

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This Item
G2911361555203291
GF 109203X hydrochloride ≥95%

Sigma-Aldrich

B6292

GF 109203X hydrochloride

GF 109203X synthetic, ≥90% (HPLC)

Sigma-Aldrich

G2911

GF 109203X

GSK-3 Inhibitor XIII The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

361555

GSK-3 Inhibitor XIII

Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I.

Sigma-Aldrich

203291

Bisindolylmaleimide I, Hydrochloride

assay

≥95%

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

-

form

solid

form

solid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

methanol: 10 mg/mL, clear, orange to red

solubility

DMSO: soluble (~1 mg/ml)

solubility

DMSO: 5 mg/mL

solubility

water: 10 mg/mL, DMSO: 20 mg/mL

biological source

synthetic (organic)

biological source

synthetic

biological source

-

biological source

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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