A9546

2-Amino-6-methylmercaptopurine

≥95%

• Synonym(s): 2-Amino-6-methylthiopurine
• Empirical Formula (Hill Notation): C₆H₇N₅S
• CAS Number: 1198-47-6
• Molecular Weight: 181.22
• EC Number: 214-833-4
• MDL number: MFCD00044701
• UNSPSC Code: 41106305
• PubChem Substance ID: 24891471
• NACRES: NA.51

Properties

• Quality Level: 200
• Assay: ≥95%
• form: solid
• SMILES string: [H]n1cnc2c(SC)nc(N)nc12
• InChI: 1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
• InChI key: YEGKYFQLKYGHAR-UHFFFAOYSA-N

Description

Application

2-Amino-6-methylmercaptopurine (6-MTG) has been used as a supplement in Dulbecco′s modified Eagles medium (DMEM) medium for the selection of gpt-expressing recombinant virus mCMVhMIEPE-gpt.lacZ (cytomegalovirus major immediate-early promotor-enhancer complex-gpt.lacz). It has also been used as a standard in high performance liquid chromatography (HPLC) to assess the activity of thiopurine methyltransferase (TPMT) enzyme.

2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.

Biochem/physiol Actions

2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H318,H335
• Precautionary Statements: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves