A1653

Albumin from human serum

lyophilized powder, ≥96% (agarose gel electrophoresis)

• Synonym(s): HSA
• CAS Number: 70024-90-7
• EC Number: 274-272-6
• MDL number: MFCD00081418
• UNSPSC Code: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

Properties

• biological source: human
• Assay: ≥96% (agarose gel electrophoresis)
• form: lyophilized powder
• mol wt: monomer calculated mol wt 66478 Da
• technique(s): ELISA: suitable; tissue culture: suitable; western blot: suitable
• impurities: HIV I and HIVII, HCV and HBsAg, tested negative
• solubility: H₂O: soluble 50 mg/mL
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)C(F)(F)C(F)(F)F
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Description

General description

Albumin (ALB) constitutes 25% of the proteins produced by the liver.[1] It is a protein of a single polypeptide chain with a thiol group.[2] The ALB gene is mapped to human 4q13.3.[3]

Application

Albumin from human serum has been used:

• in cyclophilin isomerase assay[4]
• as a component in blocking solution for immunogold quantification of amino acids and proteins in complex subcellular compartments[5]
• in G-pseudotyped HIV (PHIV) assay mixture to study its effect on GSK364735 antiviral potency[6]

Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia.[7]
It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.[8]

Biochem/physiol Actions

Albumin serves as a protein repository and functions as a binding and transport protein. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This prevents the loss of substance through excretion.[9] Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia.[1]

Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

Quality

Remainder mostly globulins

Other Notes

View more information on human serum albumin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves