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487R-9

SMAD4 (MRQ-72) Rabbit Monoclonal Antibody

Synonym(s):

Mothers Against Decapentaplegic Homolog 4 Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
Clone:
MRQ-72, monoclonal
Species reactivity:
-
Application:
—
Citations:
6
Technical Service
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biological source

rabbit

Quality Segment

500

antibody product type

primary antibodies

clone

MRQ-72, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

packaging

vial of 0.1 mL concentrate (487R-94), vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only, vial of 0.5 mL concentrate (487R-(95), vial of 1.0 mL (concentrate (487R-96)), vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only, vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only, vial of 1.0 mL pre-dilute ready-to-use (487R-97), vial of 7.0 mL pre-dilute ready-to-use (487R-98), vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only

manufacturer/tradename

Cell Marque®

isotype

IgG

control

pancreas

visualization

cytoplasmic, nuclear

General description

Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon. However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD - MQ500

RUO - MQ100

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

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Certificates of Analysis (COA)

Lot/Batch Number

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