208868

Osmium tetroxide solution

2.5 wt. % in tert-butanol

• Linear Formula: OsO₄
• CAS Number: 20816-12-0
• Molecular Weight: 254.23
• MDL number: MFCD00011150
• UNSPSC Code: 12352303
• PubChem Substance ID: 329752049
• NACRES: NA.55

Properties

• vapor pressure: 5.42 psi ( 20 °C); 6.76 psi ( 55 °C)
• form: liquid
• contains: tert-butyl hydroperoxide as stabilizer
• reaction suitability: reagent type: oxidant
• concentration: 2.5 wt. % in tert-butanol
• density: 1.0 g/mL at 20 °C; 0.811 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: O=[Os](=O)(=O)=O
• InChI: 1S/4O.Os
• InChI key: VUVGYHUDAICLFK-UHFFFAOYSA-N

Description

General description

Osmium tetroxide solution (OsO₄) is commonly used as a catalyst in various organic reactions. OsO₄ is a strong oxidizing agent and can be used to break carbon-carbon bonds. Additionally, it can be used in the cis dihydroxylation of alkenes, diastereoselective and asymmetric dihydroxylation, osmylation and oxyamination of alkenes.

Application

Osmium tetroxide solution is used as catalyst in the:

• Cis dihydroxylation of alkenes to form cis-1,2-diols.
• Direct oxidation of 1,4-dienes to yield carboxylic acids using oxone as a co-oxidant.

Osmium tetroxide can also be used:

• In the stereoselective synthesis of (+)-norrisolide.

Safety Information

• Pictograms: GHS02,GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H225,H302,H311 + H331,H315,H317,H318,H335,H336,H341
• Precautionary Statements: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 39.2 °F - closed cup
• Flash Point(C): 4 °C - closed cup