Skip to Content
Merck
All Photos(1)

Key Documents

5.34363

Sigma-Aldrich

CNTF Mimetic, P6 Peptide

Synonym(s):

CNTF Mimetic, P6 Peptide, Ciliary Neurotrophic Factor Epitope Peptide 6

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C55H90N14O16
CAS Number:
Molecular Weight:
1203.39
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL
water: 100 mg/mL

storage temp.

−20°C

General description

A brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
A brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.



Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-VGDGGLFEKKL-NH₂

Other Notes

Kazim, S., et al. 2015. Plos One.10, e0118627.
Rockenstein, E., et al. 2011. J. Alzheimer′s Dis.27, 743,
Li, B., et al. 2010. FEBS Lett.584,3359.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service