The NMR spectrum is proprietary. The product specification is only that the NMR is consistent with the structure.
487928
Nocodazole
≥99% (HPLC), solid, microtuble inhibitor, Calbiochem
Synonym(s):
Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
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About This Item
Empirical Formula (Hill Notation):
C14H11N3O3S
CAS Number:
Molecular Weight:
301.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze
Pricing and availability is not currently available.
Product Name
Nocodazole, Inhibitor of mitosis.
Quality Segment
description
RTECS - DD6521000
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
pale yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
[s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC
InChI
1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChI key
KYRVNWMVYQXFEU-UHFFFAOYSA-N
General description
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Promotes tubulin depolymerization
Promotes tubulin depolymerization
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
Other Notes
Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
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This Item | |||
|---|---|---|---|
| description Inhibitor of mitosis. | description 5 mg/mL, DMSO solution | description ≥99% (TLC), powder | description United States Pharmacopeia (USP) Reference Standard |
| assay ≥99% (HPLC) | assay - | assay ≥99% (TLC) | assay - |
| form solid | form DMSO solution | form powder | form - |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename USP |
| Quality Level 100 | Quality Level 200 | Quality Level 300 | Quality Level - |
| storage temp. 10-30°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 5 mg/mL | solubility - | solubility DMSO: soluble 10 mg/mL (may require heating), H2O: insoluble | solubility - |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Muta. 2 - Repr. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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