04-823

Anti-phospho-GluR1 (Ser831) Antibody, clone N453, rabbit monoclonal

culture supernatant, clone N453, Upstate^®

• Synonym(s): AMPA 1, AMPA-selective glutamate receptor 1, Glutamate receptor ionotropic, AMPA 1, glutamate receptor, ionotropic, AMPA 1
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Clone: N453, monoclonal
• Species reactivity: mouse, chicken, human, rat
• Application: WB
• Citations: 54

Properties

• biological source: rabbit
• Quality Segment: 100
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: N453, monoclonal
• species reactivity: mouse, chicken, human, rat
• manufacturer/tradename: Upstate^®
• technique(s): western blot: suitable
• isotype: IgG
• NCBI accession no.: NP_000818
• UniProt accession no.: P42261
• shipped in: dry ice
• target post-translational modification: phosphorylation (pSer831)
• Gene Information: human ... GRIA1(2890)

Description

General description

106 kDa

L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries.

Immunogen

KLH-conjugated, synthetic peptide containing the sequence ...QQ[pS]IN… in which pS corresponds to phospho-serine at position 831 of the GluR1 mature chain. Sequence is identical in human, rat, mouse and chicken.

Application

Western Blot Analysis:
A 1:1,000-1:4,000 dilution of this lot detected phosphorylated GluR1 from a rat brain microsomal preparation (Catalog # 12-144).

Anti-phospho-GluR1 (Ser831) Antibody, clone N453 detects level of phospho-GluR1 (Ser831) & has been published & validated for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Biochem/physiol Actions

Predicted cross-reactivity with human, mouse and chicken

Recognizes GluR1 phosphorylated on Serine 831.

Physical form

Cultured supernantant in 0.05% sodium azide.

Preparation Note

Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap.

Analysis Note

Control
Rat brain

routinely evaluated by western blot

Other Notes

Replaces: 05-823

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1