42085

1-Fluoro-2,4-dinitrobenzene

purum p.a., ≥98.0% (GC)

• Synonym(s): 2,4-Dinitro-1-fluorobenzene, DNFB, DNPF, FDNB, Sanger reagent
• Linear Formula: (O₂N)₂C₆H₃F
• CAS Number: 70-34-8
• Molecular Weight: 186.10
• Beilstein: 398632
• EC Number: 200-734-3
• MDL number: MFCD00007056
• UNSPSC Code: 12352100
• PubChem Substance ID: 57650098
• NACRES: NA.22

Properties

• grade: purum p.a.
• Assay: ≥98.0% (GC)
• form: liquid
• refractive index: n20/D 1.569 (lit.)
• bp: 178 °C/25 mmHg (lit.)
• mp: 25-27 °C (lit.)
• density: 1.482 g/mL at 25 °C (lit.)
• cation traces: Ca: ≤50 mg/kg; Cd: ≤50 mg/kg; Co: ≤50 mg/kg; Cu: ≤50 mg/kg; Fe: ≤50 mg/kg; K: ≤100 mg/kg; Na: ≤100 mg/kg; Ni: ≤50 mg/kg; Pb: ≤50 mg/kg; Zn: ≤50 mg/kg
• functional group: fluoro; nitro
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O
• InChI: 1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
• InChI key: LOTKRQAVGJMPNV-UHFFFAOYSA-N

Description

General description

1-Fluoro-2,4-dinitrobenzene(FDNB, Sanger′s reagent) is used to identify the amino acid sequence. Thischemical is used to label the free amino groups in proteins and peptides. Itcan also be used to protect the amine group, and for phenol deoxygenation. Additionally,it is a very helpful reagent for nucleophilic substitution reactions tointroduce a chromophore group to amines, phenols, and thiols.

Application

1-Fluoro-2,4-dinitrobenzene is used as a derivatization agent:

• For aminoglycoside compounds such as amikacine, tobramycine, gentamycine, sisomycine, neamine, neomycine-B and neomycine-C.

1-Fluoro-2,4-dinitrobenzene can also be used:

• To examine the kinetic analysis and analytical uses of reaction with thiols in the presence of several surfactants.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H317,H319,H335,H373
• Precautionary Statements: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 327.2 °F
• Flash Point(C): 164 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves