58979C30
SUPELCOSIL™ LC-CN (3 µm) HPLC Columns
L × I.D. 3.3 cm × 3 mm, HPLC Column
Synonym(s):
Cyanopropyl HPLC Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
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product name
SUPELCOSIL™ LC-CN HPLC Column, 3 μm particle size, L × I.D. 3.3 cm × 3 mm
material
stainless steel column
Agency
suitable for USP L10
product line
SUPELCOSIL™
feature
endcapped
manufacturer/tradename
SUPELCOSIL™
packaging
1 ea of
extent of labeling
4% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
L × I.D.
3.3 cm × 3 mm
surface area
170 m2/g
surface coverage
surface coverage 3.5 μmol/m2
matrix
silica gel, spherical particle platform
fully porous particle
matrix active group
cyano phase
particle size
3 μm
pore size
120 Å
pH range
2-7.5
application(s)
food and beverages
separation technique
hydrophilic interaction (HILIC)
normal phase
reversed phase
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General description
The LC-CN phase is often used as a substitute for silica because it offers the advantages of a bonded phase (such as quick equilibration, and less sensitivity to small changes of the water content in the mobile phase). More often, however, the LC-CN column is operated under reversed-phase mobile phase conditions.
Application
- Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: : This study presents a validated HPLC-UV method for monitoring Mycophenolic Acid in human plasma, emphasizing the role of internal standardization in accuracy and precision of the results. The SUPELCOSIL™ LC-CN HPLC column was utilized for its effective separation capabilities (Kunicki and Wróbel, 2021).
- An Improved HPLC Method for Therapeutic Drug Monitoring of Daunorubicin, Idarubicin, Doxorubicin, Epirubicin, and Their 13-Dihydro Metabolites in Human Plasma: This paper details an enhanced HPLC method for monitoring various anthracycline drugs in human plasma. The use of the SUPELCOSIL™ LC-CN HPLC column improved the detection and quantification of these drugs and their metabolites (Fogli et al., 1999).
- Analysis of Diltiazem and Desacetyldiltiazem in Serum by High-Performance Liquid Chromatography: This research focused on developing a precise HPLC method to analyze diltiazem and its metabolite in serum, employing the SUPELCOSIL™ LC-CN HPLC column for effective separation and detection (Paczkowski et al., 1995).
- High-Performance Liquid Chromatographic Method for the Determination of Eclanamine and Its N-Desmethyl and N,N-Didesmethyl Metabolites in Urine: This study describes a robust HPLC method for determining eclanamine and its metabolites in urine, utilizing the SUPELCOSIL™ LC-CN HPLC column for its high-resolution capabilities (Lakings et al., 1988).
Legal Information
SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC
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D Paczkowski et al.
Polish journal of pharmacology, 47(5), 429-434 (1995-09-01)
This paper describes a simple high-performance liquid chromatographic (HPLC) method for the determination of diltiazem and desacetyldiltiazem in human serum. After basic methyl-tert-butyl ether extraction and back-extraction with hydrochloric acid, the drug and its metabolite was injected into a Supelcosil
S Fogli et al.
Therapeutic drug monitoring, 21(3), 367-375 (1999-06-12)
A single high-performance liquid chromatography (HPLC) method, suitable for the analysis of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites is validated in the present study. Preparation of plasma samples was performed by a first extraction of analytes with a
H Kataoka et al.
Journal of chromatography. B, Biomedical sciences and applications, 731(2), 353-359 (1999-10-08)
The technique of automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) was evaluated for the determination of ranitidine. In-tube SPME is an extraction technique for organic compounds in aqueous samples, in which analytes are extracted
H Kataoka et al.
Journal of analytical toxicology, 24(4), 257-265 (2000-06-29)
A simple and rapid method for the determination of amphetamine, methamphetamine, and their 3,4-methylenedioxy derivatives in urine samples was developed using automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS). In-tube SPME is an extraction technique
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