V4265

VU 590 dihydrochloride hydrate

≥ (HPLC)

• Empirical Formula (Hill Notation): C₂₄H₃₂N₄O₇·2HCl · xH₂O
• Molecular Weight: 561.46 (anhydrous basis)
• MDL number: MFCD16875439
• UNSPSC Code: 12352203
• PubChem Substance ID: 329829050

Properties

• form: solid
• storage condition: desiccated
• solubility: deionized water: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cl.Cl.[O-][N+](=O)c1ccc(CN2CCOCCOCCN(CCOCC2)Cc3ccc(cc3)[N+]([O-])=O)cc1
• InChI: 1S/C24H32N4O7.2ClH.H2O/c29-27(30)23-5-1-21(2-6-23)19-25-9-13-33-14-10-26(12-16-35-18-17-34-15-11-25)20-22-3-7-24(8-4-22)28(31)32;;;/h1-8H,9-20H2;2*1H;1H2
• InChI key: UARRNDBWOZCTNV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

VU590 inhibits ROMK at sub-micromolar affinity (294 nM) and Kir7.1

VU590 inhibits ROMK at sub-micromolar affinity (294 nM) and Kir7.1 at low micromolar affinity, but it does not inhibit Kir2.1 or Kir4.1. VU590 appears to act by blocking the ion permeation pathway of the channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable