4-[[4-[[2-(4-Amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide, 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide, SUN 11602, SUN-11602
Orally active basic fibroblast growth factor (bFGF, FGF2) mimetic with neuroprotective efficacy in vitro and in vivo.
SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic that protects against glutamate toxicity in primary rat cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a rat hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).
Basic fibroblast growth factor (bFGF/FGF-2) is known to possess neuroprotective and neurite outgrowth activity properties. In this study, the effects of a novel synthetic compound that mimics the neuroprotective properties of bFGF - SUN11602 - were examined in vitro and
Basic fibroblast growth factor (FGF-2/bFGF) possesses neuroprotective activity and promotes cell proliferation. In this study, the novel synthetic compound 4-({4-[[(4-amino-2,3,5,6-tetramethylanilino)acetyl](methyl)amino]-1-piperidinyl}methyl)benzamide (SUN11602) exhibited neuroprotective activities similar to those of FGF-2 without promoting cell proliferation. In primary cultures of hippocampal neurons, stimulation
Archiv der Pharmazie, 354(8), e2100082-e2100082 (2021-05-09)
Small molecules have gained considerable interest in regenerative medicine, as they can effectively modulate cell fates in a spatiotemporal controllable fashion. A continuous challenge in the field represents genuine mimicry or activation of growth factor signaling with small molecules. Here
Psoriasis is a common chronic immune-mediated disease that often has a serious negative impact on the physical and mental health of patients. Dihydroartemisinin (DHA) is a drug with anti-fibrotic and anti-inflammatory effects that may be involved in the autoimmune regulation
ACS chemical neuroscience, 4(2), 266-276 (2013-02-21)
Basic fibroblast growth factor (bFGF) offers some measure of protection against excitotoxic neuronal injuries by upregulating the expression of the calcium-binding protein calbindin-D28k (Calb). The newly synthesized small molecule 4-({4-[[(4-amino-2,3,5,6-tetramethylanilino)acetyl](methyl)amino]-1-piperidinyl}methyl)benzamide (SUN11602) mimics the neuroprotective effects of bFGF, and thus, we
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