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SML3220

Sigma-Aldrich

GSK923295

≥95% (HPLC)

Synonym(s):

3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide, GSK 923295, GSK 923295A

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About This Item

Empirical Formula (Hill Notation):
C32H38ClN5O4
CAS Number:
1088965-37-0
Molecular Weight:
592.13
MDL number:
MFCD16038931
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

GSK923295 is an allosteric inhibitor of CENP-E kinesin motor ATPase activity. It inhibits release of inorganic phosphate and stabilizes CENP-E motor domain interaction with microtubules, which causes failure of metaphase chromosome alignment and induces mitotic arrest. GSK923295 induces tumor cell apoptosis and tumor regression

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295
ACS Medicinal Chemistry Letters, 1(1), 30-34 (2010)
Zhen-Yu She et al.
Cell death discovery, 6, 25-25 (2020-05-01)
Kinesin-7 CENP-E is an essential kinetochore motor required for chromosome alignment and congression. However, the specific functions of CENP-E in the spermatogenic cells during spermatogenesis remain unknown. In this study, we find that CENP-E proteins are expressed in the spermatogonia
Rudolf Pisa et al.
Cell chemical biology, 27(7), 850-857 (2020-05-23)
Aberrant chromosome numbers in cancer cells may impose distinct constraints on the emergence of drug resistance-a major factor limiting the long-term efficacy of molecularly targeted therapeutics. However, for most anticancer drugs we lack analyses of drug-resistance mechanisms in cells with

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