The solubility of this product has not been tested by QC, and there is no solubility information available in our database or COA. However, according to a Google search, the solubility of Ac2-26 trifluoroacetate is as follows:
In Vitro:
- H2O: 0.11 mg/mL (0.03 mM; ultrasonic and adjust pH to 13 with NaOH)
- DMSO: < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
In Vivo:
- Solvent 1: PBS
- Solubility: 1 mg/mL (0.31 mM)
- Clarity: Clear solution
- Requirements: Ultrasonic and adjust pH to 9 with NaOH
SML3198
Ac2-26 trifluoroacetate
≥98% (HPLC)
Synonym(s):
Ac2-26 TFA, LC1 trifluoroacetate, Lipocortin 1- trifluoroacetate, Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH trifluoroacetate, Annexin A1 trifluoroacetate, AnxA1 trifluoroacetate
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1 MG
£73.10
About This Item
Empirical Formula (Hill Notation):
C141H210N32O44S
Molecular Weight:
3089.43
UNSPSC Code:
12352107
NACRES:
NA.77
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General description
Ac2-26 is a Lipocortin 1/Annexin 1 Peptide Mimetic, derived from the N-terminal region of annexin A1 (AnxA1). It contains residues 2–26 of AnxA1.[1] Ac2-26 activates formyl peptide receptor family members formyl peptide receptor (FPR), FPR-like (FPRL) 1 and FPRL2. It exhibits an anti-inflammatory effect by inhibiting the adhesion and transmigration of leukocytes (leukocyte extravasation). This facilitates the growth and migration of epithelial cells, aiding in tissue repair.[2] Ac2-26 also serves as a cardioprotective peptide. It is observed that Ac2-26 reduces acute lung injury caused by ischemia and reperfusion.[1]
Biochem/physiol Actions
Lipocortin 1/Annexin 1 Peptide Mimetic; activates formyl peptide receptor family
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Liang Wu et al.
Diabetes, 70(10), 2192-2203 (2021-06-10)
Inflammation and abnormal metabolism play important roles in the pathogenesis of diabetic nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation resolution and improves metabolism. In this study, we assess the effects of ANXA1 in diabetic mice and proximal tubular epithelial
Josh C Woloszynek et al.
The Journal of biological chemistry, 287(41), 34101-34109 (2012-08-11)
Neutrophil serine proteases play an important role in inflammation by modulating neutrophil effector functions. We have previously shown that neutrophils deficient in the serine proteases cathepsin G and neutrophil elastase (CG/NE neutrophils) exhibit severe defects in chemokine CXCL2 release and
José Marcos Sanches et al.
Cells, 10(1) (2021-01-15)
This study evaluated the role of endogenous and exogenous annexin A1 (AnxA1) in the activation of the NLRP3 inflammasome in isolated peritoneal neutrophils. C57BL/6 wild-type (WT) and AnxA1 knockout mice (AnxA1-/-) received 0.3% carrageenan intraperitoneally and, after 3 h, the
Marvin Rüger et al.
Journal of neuroinflammation, 17(1), 325-325 (2020-10-31)
Bacterial meningitis is still a cause of severe neurological disability. The brain is protected from penetrating pathogens by the blood-brain barrier and the innate immune system. The invading pathogens are recognized by pattern recognition receptors including the G-protein-coupled formyl peptide
Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury
Liao WI, et al.
International Journal of Molecular Sciences, 18(8) (2017)
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What is the solubility of the product SML3198, Ac2-26 trifluoroacetate?
1 answer-
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Ac2-26 trifluoroacetate ≥98% (HPLC) (sigmaaldrich.com) 上記を購入したのですが、溶かす溶媒は蒸留水で良いのでしょうか？またストックする濃度についても教えてください。
1 answer-
The solubility of this product is not determined. However, other sources suggest that this compound is soluble in Phosphate Buffered Saline at 1 mg/mL. Sonication or increasing the pH to 9 by adding NaOH drop-wise may be required.
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